Measurement and reversal of the direct oral anticoagulants
نویسندگان
چکیده
منابع مشابه
Reversal of direct oral anticoagulants
Reversal agents for direct oral anticoagulants (DOACs), including factor X inhibitors and direct thrombin inhibitors, are a major concern in clinical practice. After DOACs were introduced and became widely used as an alternative for vitamin K antagonists in the management of venous thromboembolism and nonvalvular atrial fibrillation, the need for effective reversal agents has increased, particu...
متن کاملThe Reversal of Direct Oral Anticoagulants in Animal Models
Several direct oral anticoagulants (DOACs), including direct thrombin and factor Xa inhibitors, have been approved as alternatives to vitamin K antagonist anticoagulants. As with any anticoagulant, DOAC use carries a risk of bleeding. In patients with major bleeding or needing urgent surgery, reversal of DOAC anticoagulation may be required, presenting a clinical challenge. The optimal strategy...
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Although the options for therapeutic modalities such as chemotherapy and antibiotics have flourished, anticoagulant management has remained stagnant since the first agents were developed during World War II. Traditional anticoagulants widely used to treat thromboembolic disease include heparin-based drugs and warfarin. These drugs are cumbersome to administer. They have a narrow therapeutic win...
متن کاملThe laboratory and the direct oral anticoagulants.
Although direct oral anticoagulants do not need laboratory testing for dose adjustment, there are instances when laboratory measurement of the drug anticoagulant effect may be useful. They include before initiation of treatment, before surgical or invasive procedures, on the occasion of hemorrhagic or thrombotic events, and whenever immediate reversal of anticoagulation is needed. Choice of tes...
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ژورنال
عنوان ژورنال: Blood Reviews
سال: 2017
ISSN: 0268-960X
DOI: 10.1016/j.blre.2016.08.006